2-[2-(2-Azidoethoxy)ethoxy]ethanamine

2-[2-(2-Azidoethoxy)ethoxy]ethanamine - Names and Identifiers

Name	2-[2-(2-Azidoethoxy)ethoxy]ethanamine
Synonyms	N3-PEG2-NH2 Azido-PEG2-NH2 Azido-PEG2-Amine N3-PEG2-CH2CH2NH2 Azido-PEG2-C2-amine Amino-PEG2-azide,NH2-PEG2-N3 2-[2-(2-Azidoethoxy)ethoxy]ethanamine 2-[2-(2-Azido-ethoxy)-ethoxy]-ethylamine
CAS	166388-57-4

2-[2-(2-Azidoethoxy)ethoxy]ethanamine - Physico-chemical Properties

Molecular Formula	C6H14N4O2
Molar Mass	174.2
Storage Condition	2-8℃
Physical and Chemical Properties	Bioactive Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Azido-PEG2-C2-amine is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC).
Use	Use 2-[2-(2-azidoethoxy) ethoxy] ethylamine can be used as a pharmaceutical synthesis intermediate.

2-[2-(2-Azidoethoxy)ethoxy]ethanamine - Upstream Downstream Industry

Raw Materials

Ethanamine, 2-[2-(2-bromoethoxy)ethoxy]-
BOC-1-AMINO-3,6-DIOXA-8-OCTANEDIAMINE
1,8-Diamino-3,6-dioxaoctane
Ethane, 1,2-bis(2-bromoethoxy)-
t-Boc-N-Amido-PEG2-Azide
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Triethylene Glycol Dimethanesulfonate
TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
1,8-Diazido-3,5-dioxaoctane
1,2-Bis(2-chloroethoxy)ethane
Triethylene glycol

2-[2-(2-Azidoethoxy)ethoxy]ethanamine - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	5.741 ml	28.703 ml	57.405 ml
5 mM	1.148 ml	5.741 ml	11.481 ml
10 mM	0.574 ml	2.87 ml	5.741 ml
5 mM	0.115 ml	0.574 ml	1.148 ml

Last Update：2024-01-02 23:10:35

2-[2-(2-Azidoethoxy)ethoxy]ethanamine - Uses and synthesis methods

Preparation

200 mg PGA copolymer (1.55 moles of glutamic acid 1eq) was added to a round neck flask.) Suspended in 10mL of water. 128.7mg(0.465mmol,0.3 equivalent) DMTMM was obtained, chloride was added and dissolved in 5mL of water. Add 2-[2-(2-azidoethoxy) ethoxy] ethylamine (0.93 mmol, 0.6 equivalents) for 10 minutes. The pH was adjusted to 8 by adding some 1MNaHCO3. Stir at room temperature to allow the reaction to proceed overnight. Because all by-products are water soluble, ultrafiltration (membrane thickness of 3.000Mw) or size exclusion chromatography with SephadexG25 column. A colorless amorphous solid was obtained and freeze-dried with a yield of 80-90%.

biological activity

Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PROTAC linker, belonging to PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG2-C2-amine is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC).

target

PEGs

Non-cleavable

in vitro study

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Last Update：2024-04-09 18:58:34